Current state-of-the-art capabilities for generalized biofabrication reside primarily in large, well-established organizations (such as the Broad Institute) and biotechnology companies (such as Zymergen). The state-of-the-art, however, is still a somewhat ad-hoc assemblage of product-oriented tools, customized software local to that institution, proprietary data sets, custom automation solutions, and customized data-logging and analysis systems. Often, industry views its proprietary approach to data flow and informatics as unique and as a large part of their value-proposition and tends to sequester informatics gains to particular institutions. However, to address this, there is a rapidly growing number of public-funded, non-commercial bio-foundries, which has recently resulted in the establishment of the Global Biofoundries Alliance.1Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., … Freemont, P. S. (2019). Building a global alliance of biofoundries. Nature Communications, 10(1), 2040. View publication. The aims of the Alliance are to establish open technology platforms that will allow the sharing of automation workflows and protocols, software, reference materials and best practices which may lead to new standards for measurement and data, as well as global capacity for establishing optimal manufacturing processes for synthetic biology.
Breakthrough Capabilities & Milestones
Standardized informatics tools, data, and automation platforms for efficient and collaborative use and integration of data in order to develop novel products more quickly.
Establish communications and networks to develop democratized platforms for data exchange and automation across industry and academia.
Democratized platform for data exchange related to standard/model microorganisms.
Initial development of a database of organisms beyond E. coli and S. cerevisiae (i.e., a database of non-model organisms), that leverages existing databases, to integrate predicted pathways, and -omics data that confirm specific production of a compound of interest.
Democratized platform for non-model organisms and microbial communities.
Democratized suite of platforms that can be utilized across different model systems.
Full machine learning capabilities and ability of algorithms to run greater than 90% of the DBTL+automation cycle.
- Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., … Freemont, P. S. (2019). Building a global alliance of biofoundries. Nature Communications, 10(1), 2040. View publication.