Manufacturing of consumable and infrastructure products via synthetic biology, including food, textiles, building materials, and packaging.

Engineering Biology

Industrial Biotechnology Challenge:

Scalable production of novel and existing products that are more sustainable and economically- and environmentally-friendly.

Manufacturing of consumable and infrastructure products via synthetic biology, including food, textiles, building materials, and packaging.

Engineering Biology Objectives & Technical Achievements

Innovations in bio-based manufacturing of commodity products.

Engineering DNA	Biomolecular Engineering	Host Engineering	Data Science
Highly efficient organismal gene and genome editing.	Enable more efficient and rapid engineering of orthogonal chemical communications pathways between cells. Heterologous pathway transformation into organisms from different kingdoms.	General molecular toolbox that can be applied to a wide range of hosts.	Screening capabilities for bio-based production. Databases and foundries for microbial isolates.

Engineering DNA

Biomolecular Engineering

Host Engineering

Data Science

Highly efficient organismal gene and genome editing.

Enable more efficient and rapid engineering of orthogonal chemical communications pathways between cells.

Heterologous pathway transformation into organisms from different kingdoms.

General molecular toolbox that can be applied to a wide range of hosts.

Screening capabilities for bio-based production.

Databases and foundries for microbial isolates.

Synthetic and natural organisms that can convert agricultural wastes into commodity products.

Engineering DNA	Biomolecular Engineering	Host Engineering	Data Science
Ability to synthesize, edit, assemble, and deliver many genes and regulatory components in a single cell. Ability to edit genomes of diverse hosts, including microbes, fungi, and protists to find hosts that are naturally more efficient or that have more efficient pathways that can be placed into heterologous hosts.	Engineered proteins and large complexes with efficient catalytic capabilities for conversion of bulk agricultural waste into products with downstream applicability. Regulatory components (including sensors and networks) that program the organism to adapt to the feedstock, intermediates, and side products.	General molecular toolbox that can be applied to a wide range of hosts. Engineer hosts that can sustain production yield and efficiency under a wide range of stress conditions.	Screening capabilities for bio-based production. Libraries and foundries for microbial isolates. Analysis and prediction of metagenomic data.

Engineering DNA

Biomolecular Engineering

Host Engineering

Data Science

Ability to synthesize, edit, assemble, and deliver many genes and regulatory components in a single cell.

Ability to edit genomes of diverse hosts, including microbes, fungi, and protists to find hosts that are naturally more efficient or that have more efficient pathways that can be placed into heterologous hosts.

Engineered proteins and large complexes with efficient catalytic capabilities for conversion of bulk agricultural waste into products with downstream applicability.

Regulatory components (including sensors and networks) that program the organism to adapt to the feedstock, intermediates, and side products.

General molecular toolbox that can be applied to a wide range of hosts.

Engineer hosts that can sustain production yield and efficiency under a wide range of stress conditions.

Screening capabilities for bio-based production.

Libraries and foundries for microbial isolates.

Analysis and prediction of metagenomic data.