Engineering Biology Objectives & Technical Achievements
Develop rapid, reliable diagnostics to detect viral infections.
Engineering DNA | Biomolecular Engineering | Host Engineering | Data Science |
---|---|---|---|
Rapid, high-fidelity DNA synthesis for development and production of sensing technologies. Gene editing technologies for building cell-based sensors. |
Sensitive and specific molecular sensing technologies, such as molecular probes or DNA amplification. |
Cell-expressed reporters for infection. Synthetic epigenetic silencing of viral DNA. |
Point-of-care (POC) and/or microfluidic systems for automating patient sample preparation. Cheap and fast sequencing of viral infection markers and patient susceptibility biomarkers. |
Develop tools to treat viral infections.
Engineering DNA | Biomolecular Engineering | Host Engineering | Data Science |
---|---|---|---|
New gene editing tools to precisely neutralize or excise viral sequences from host genomes. Scaled-up synthesis of high quality DNA encoding anti-viral gene circuits. |
Rapid design and synthesis of customized, targeted endonucleases for inhibiting viral replication. |
Synthetic epigenetic silencing of viral DNA. Development of cell and tissue models to screen and test anti-viral interventions in situ. |
Systems biology approaches to identifying critical molecular weaknesses in viral function as drug targets. Simulations to predict pace and breadth of epidemics and impact of molecular interventions. |